During a migraine attack, a nerve in the brain releases a protein called calcitonin gene-related peptide (CGRP). CGRP attaches to and activates receptors in the brain and can play a role in migraine attacks. Nurtec ODT helps block these receptors. This can help stop the pain signals, swelling of blood vessels, and inflammation that occurs in the brain during a migraine. Nurtec ODT works differently from triptans.