When should I take Nurtec™ ODT? April 07, 2020 20:35 Updated Follow It's best to take Nurtec ODT when your migraine starts. You can take Nurtec ODT up to once per 24 hours. Related articles Can I take Nurtec™ ODT alongside my preventive migraine medication? How much does Nurtec™ ODT cost with Cove? How does Nurtec™ ODT work? How do I get Nurtec™ ODT through Cove? What are antidepressants for migraine treatment?